1. Persistent Sadness: A pervasive and enduring low mood, often without a clear external cause.
2. Loss of Interest or Pleasure: Diminished interest or enjoyment in activities that were once pleasurable.
3. Changes in Sleep Patterns: Insomnia or hypersomnia, involving difficulties falling asleep, staying asleep, or excessive sleeping.
4. Fatigue: Persistent feelings of tiredness and lack of energy.
5. Feelings of Worthlessness or Guilt: Negative self-perception, unwarranted guilt, or feelings of worthlessness.
6. Difficulty Concentrating: Impaired ability to focus, make decisions, or complete tasks.
7. Changes in Appetite: Significant changes in appetite leading to weight loss or gain.
8. Psychomotor Agitation or Retardation: Observable changes in physical movements, either accelerated or slowed.
9. Suicidal Thoughts: Thoughts of death or suicide, or actual suicide attempts.

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